6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells

6- and 8-Prenylnaringenin, Novel Natural Histone Deacetylase Inhibitors Found in Hops, Exert Antitumor Activity on Melanoma Cells

Background/Aims: Prenylnaringenins are natural prenylflavonoids with anticancer properties. However, the underlying mechanisms have not been elucidated yet. Here we report a novel mode of action of 6- and 8-prenylnaringenin (PN) on human melanoma cells: Inhibition of cellular histone deacetylases (H...

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Bibliographic Details
Main Authors: Sascha Venturelli, Heike Niessner, Tobias Sinnberg, Alexander Berger, Markus Burkard, Corinna Urmann, Kathrin Donaubauer, Alexander Böcker, Christian Leischner, Herbert Riepl, Jan Frank, Ulrich M Lauer, Claus Garbe, Christian Busch
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
6-prenylnaringenin
8-prenylnaringenin
6-PN
8-PN
HDAC
Histone deacetalyse inhibition
Melanoma
Therapy
Hops
Online Access:https://www.karger.com/Article/FullText/495275

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https://www.karger.com/Article/FullText/495275

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