The reversal effects of 3-bromopyruvate on multidrug resistance in vitro and in vivo derived from human breast MCF-7/ADR cells.

The reversal effects of 3-bromopyruvate on multidrug resistance in vitro and in vivo derived from human breast MCF-7/ADR cells.

<h4>Purpose</h4>P-glycoprotein mediated efflux is one of the main mechanisms for multidrug resistance in cancers, and 3-Bromopyruvate acts as a promising multidrug resistance reversal compound in our study. To test the ability of 3-Bromopyruvate to overcome P-glycoprotein-mediated multid...

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Bibliographic Details
Main Authors: Long Wu, Jun Xu, Weiqi Yuan, Baojian Wu, Hao Wang, Guangquan Liu, Xiaoxiong Wang, Jun Du, Shaohui Cai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0112132

Internet

https://doi.org/10.1371/journal.pone.0112132

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