NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

NUDT15 Polymorphism Confer Increased Susceptibility to Thiopurine-Induced Leukopenia in Patients With Autoimmune Hepatitis and Related Cirrhosis

The aim of this study was to investigate the influence of NUDT15 R139C and thiopurine S-methyltransferase (TPMT) on azathioprine (AZA) induced leukopenia in patients with autoimmune hepatitis (AIH) and related cirrhosis. A total of 149 Chinese AIH patients with a history of AZA treatment were retros...

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Bibliographic Details
Main Authors: Xiaoli Fan, Dandan Yin, Ruoting Men, Heng Xu, Li Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
azathioprine
leukopenia
NUDT15
autoimmune hepatitis
cirrhosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00346/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00346/full

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