ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

ICE1 promotes the link between splicing and nonsense-mediated mRNA decay

The nonsense-mediated mRNA decay (NMD) pathway detects aberrant transcripts containing premature termination codons (PTCs) and regulates expression of 5–10% of non-aberrant human mRNAs. To date, most proteins involved in NMD have been identified by genetic screens in model organisms; however, the in...

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Bibliographic Details
Main Authors: Thomas D Baird, Ken Chih-Chien Cheng, Yu-Chi Chen, Eugen Buehler, Scott E Martin, James Inglese, J Robert Hogg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-03-01
Series:eLife
Subjects:
nonsense-mediated mRNA decay
siRNA screen
exon junction complex
RNA quality control
ICE1
UPF3B
Online Access:https://elifesciences.org/articles/33178

Internet

https://elifesciences.org/articles/33178

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