Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology

The human APOE*4 allele is associated with an early age of onset and increased risk of Alzheimer's disease (AD). Long before the onset of AD, cognitive deficits can be identified in APOE*4 carriers. We examined neurons in the lateral amygdala of young apolipoprotein (apo) E3 and apoE4 targeted...

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Bibliographic Details
Main Authors: Chunsheng Wang, Wilkie A. Wilson, Scott D. Moore, Brian E. Mace, Nobuyo Maeda, Donald E. Schmechel, Patrick M. Sullivan
Format: Article
Language:English
Published: Elsevier 2005-03-01
Series:Neurobiology of Disease
Subjects:
Alzheimer
EPSP (excitatory postsynaptic)
Cognitive
Transmission
Morphometry
Amygdala
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104002621

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http://www.sciencedirect.com/science/article/pii/S0969996104002621

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