ISG15 Promotes ERK1 ISGylation, CD8+ T Cell Activation and Suppresses Ovarian Cancer Progression

ISG15 Promotes ERK1 ISGylation, CD8+ T Cell Activation and Suppresses Ovarian Cancer Progression

Increased number of tumor-infiltrating CD8+ lymphocytes is associated with improved survival in patients with advanced stage high grade serous ovarian cancer (HGSOC) but the underlying molecular mechanism has not been thoroughly explored. Using transcriptome profiling of microdissected HGSOC tissue...

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Bibliographic Details
Main Authors: Tsz-Lun Yeung, Ching Chou Tsai, Cecilia S. Leung, Chi-Lam Au Yeung, Melissa S. Thompson, Karen H. Lu, Ralph S. Freedman, Michael J. Birrer, Kwong-Kwok Wong, Samuel C. Mok
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Cancers
Subjects:
ovarian cancer
ISG15
CD8+ lymphocyte
interferon
ISGylation
Online Access:https://www.mdpi.com/2072-6694/10/12/464

Internet

https://www.mdpi.com/2072-6694/10/12/464

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