Identification of functional DNA variants in the constitutive promoter region of <it>MDM2</it>
<p>Abstract</p> <p>Although mutations in the oncoprotein murine double minute 2 (MDM2) are rare, <it>MDM2</it> gene overexpression has been observed in several human tumors. Given that even modest changes in MDM2 levels might influence the p53 tumor suppressor signaling...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-09-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/6/1/15 |