Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix

Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix

Rewiring of synaptic circuitry pertinent to memory formation has been associated with morphological changes in dendritic spines and with extracellular matrix (ECM) remodeling. Here, we mechanistically link these processes by uncovering a signaling pathway involving the serotonin 5-HT7 receptor (5-HT...

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Bibliographic Details
Main Authors: Monika Bijata, Josephine Labus, Daria Guseva, Michał Stawarski, Malte Butzlaff, Joanna Dzwonek, Jenny Schneeberg, Katrin Böhm, Piotr Michaluk, Dmitri A. Rusakov, Alexander Dityatev, Grzegorz Wilczyński, Jakub Wlodarczyk, Evgeni Ponimaskin
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
dendritic spines
synaptic plasticity
proteolysis
extracellular matrix
MMP-9
CD44
5-HT7R
Cdc42
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306484

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http://www.sciencedirect.com/science/article/pii/S2211124717306484

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