Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

Polarizing receptor activation dissociates fibroblast growth factor 2 mediated inhibition of myelination from its neuroprotective potential

Abstract Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a factor up-regulated by astrocytes in active inflammatory lesions that disrupts my...

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Bibliographic Details
Main Authors: Katja Thümmler, Eran Rom, Thomas Zeis, Maren Lindner, Sarah Brunner, John J. Cole, Diana Arseni, Steve Mücklisch, Julia M. Edgar, Nicole Schaeren-Wiemers, Avner Yayon, Christopher Linington
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Multiple sclerosis and Neuroinflammation
Remyelination
Neuroprotection
Neuroinflammation
Oligodendrocyte
Online Access:https://doi.org/10.1186/s40478-019-0864-6

Internet

https://doi.org/10.1186/s40478-019-0864-6

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