Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling

Process Analytical Technology for Advanced Process Control in Biologics Manufacturing with the Aid of Macroscopic Kinetic Modeling

Productivity improvements of mammalian cell culture in the production of recombinant proteins have been made by optimizing cell lines, media, and process operation. This led to enhanced titers and process robustness without increasing the cost of the upstream processing (USP); however, a downstream...

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Bibliographic Details
Main Authors: Martin Kornecki, Jochen Strube
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Bioengineering
Subjects:
process analytical technology
macroscopic modeling
biologics manufacturing
upstream
downstream
turbidity
Raman
Chinese hamster ovary
process control
Online Access:http://www.mdpi.com/2306-5354/5/1/25

Internet

http://www.mdpi.com/2306-5354/5/1/25

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