Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections

Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections

Viral pneumonias cause profound worldwide morbidity, necessitating novel strategies to prevent and treat these potentially lethal infections. Stimulation of intrinsic lung defenses via inhalation of synergistically acting Toll-like receptor (TLR) agonists protects mice broadly against pneumonia, inc...

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Bibliographic Details
Main Authors: Carson T. Kirkpatrick, Yongxing Wang, Miguel M. Leiva Juarez, Pooja Shivshankar, Jezreel Pantaleón García, Alexandria K. Plumer, Vikram V. Kulkarni, Hayden H. Ware, Fahad Gulraiz, Miguel A. Chavez Cavasos, Gabriela Martinez Zayes, Shradha Wali, Andrew P. Rice, Hongbing Liu, James M. Tour, William K. A. Sikkema, Ana S. Cruz Solbes, Keith A. Youker, Michael J. Tuvim, Burton F. Dickey, Scott E. Evans
Format: Article
Language:English
Published: American Society for Microbiology 2018-05-01
Series:mBio
Subjects:
inducible resistance
Toll-like receptors
lung epithelium
mucosal immunity
reactive oxygen species
viral pneumonia
Online Access:https://doi.org/10.1128/mBio.00696-18

Internet

https://doi.org/10.1128/mBio.00696-18

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