Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection.

Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection.

Hepatitis B virus (HBV) persistence is facilitated by exhaustion of CD8 T cells that express the inhibitory receptor programmed cell death-1 (PD-1). Improvement of the HBV-specific T cell function has been obtained in vitro by inhibiting the PD-1/PD-ligand 1 (PD-L1) interaction. In this study, we ex...

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Bibliographic Details
Main Authors: Jia Liu, Ejuan Zhang, Zhiyong Ma, Weimin Wu, Anna Kosinska, Xiaoyong Zhang, Inga Möller, Pia Seiz, Dieter Glebe, Baoju Wang, Dongliang Yang, Mengji Lu, Michael Roggendorf
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3879364?pdf=render

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http://europepmc.org/articles/PMC3879364?pdf=render

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