Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression

Nuclear Tau, p53 and Pin1 Regulate PARN-Mediated Deadenylation and Gene Expression

While nuclear tau plays a role in DNA damage response (DDR) and chromosome relaxation, the mechanisms behind these functions are not fully understood. Here, we show that tau forms complex(es) with factors involved in nuclear mRNA processing such as tumor suppressor p53 and poly(A)-specific ribonucle...

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Bibliographic Details
Main Authors: Jorge Baquero, Sophia Varriano, Martha Ordonez, Pawel Kuczaj, Michael R. Murphy, Gamage Aruggoda, Devon Lundine, Viktoriya Morozova, Ali Elhadi Makki, Alejandra del C. Alonso, Frida E. Kleiman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
mRNA processing
p53
nuclear tau
Pin1
cellular DNA damage
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00242/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2019.00242/full

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