Transcription factor E2F3a regulates CASP8AP2 transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia

Transcription factor E2F3a regulates CASP8AP2 transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia

Abstract Background Low expression of E2F3a and caspase 8 associated protein 2 (CASP8AP2) are associated with poor prognosis of childhood acute lymphoblastic leukemia (ALL). Methods Dual-luciferase reporter assay and wild type as well as four mutated types of reporter plasmids were used to demonstra...

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Bibliographic Details
Main Authors: Fei-Fei Liu, Kai-Ling Wang, Li-Ping Deng, Xiao Liu, Min-yuan Wu, Tian-You Wang, Lei Cui, Zhi-Gang Li
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Cancer Cell International
Subjects:
Childhood acute lymphoblastic leukemia
E2F3a
CASP8AP2
Transcription regulation
Chemotherapeutic sensitivity
Online Access:http://link.springer.com/article/10.1186/s12935-018-0531-1

Internet

http://link.springer.com/article/10.1186/s12935-018-0531-1

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