Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity.

Interferon-β induces cellular senescence in cutaneous human papilloma virus-transformed human keratinocytes by affecting p53 transactivating activity.

Interferon (IFN)-β inhibits cell proliferation and affects cell cycle in keratinocytes transformed by both mucosal high risk Human Papilloma Virus (HPV) and cutaneous HPV E6 and E7 proteins. In particular, upon longer IFN-β treatments, cutaneous HPV38 expressing cells undergo senescence. IFN-β appea...

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Bibliographic Details
Main Authors: Maria V Chiantore, Serena Vannucchi, Rosita Accardi, Massimo Tommasino, Zulema A Percario, Gabriele Vaccari, Elisabetta Affabris, Gianna Fiorucci, Giovanna Romeo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3353995?pdf=render

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http://europepmc.org/articles/PMC3353995?pdf=render

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