Developing efficient protocols for synthesis, antiosteoarthritic, antiinflammatory assessments and docking studies of nitrogen-containing bisphosphonate derivatives

Developing efficient protocols for synthesis, antiosteoarthritic, antiinflammatory assessments and docking studies of nitrogen-containing bisphosphonate derivatives

We report herein, two synthetic approaches to three types of nitrogen-containing bisphosphonates (N-BPs) in moderate to high yields (58–88%). Ester cleavage of selected bisphosphonates was undertaken to obtain their N-BP-acid analogs. Based on the reported bisphosphonate properties and the prospecti...

Full description

Bibliographic Details
Main Authors: Wafaa M. Abdou, Neven A. Ganoub, Mohamed A.H. Ismail, Eman Sabry, Reham F. Barghash, Athina Geronikaki
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Arabian Journal of Chemistry
Subjects:
N-bisphosphonates
N-bisphosphonic acids
Antichronic inflammation
CAMM-drug research
Docking studies
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535216300144

Internet

http://www.sciencedirect.com/science/article/pii/S1878535216300144

Similar Items