NMR-Guided Repositioning of Non-SteroidalAnti-Inflammatory Drugs into Tight Junction Modulators

NMR-Guided Repositioning of Non-SteroidalAnti-Inflammatory Drugs into Tight Junction Modulators

Bioavailability is a major bottleneck in the clinical application of medium molecular weight therapeutics, including protein and peptide drugs. Paracellular transport of these molecules is hampered by intercellular tight junction (TJ) complexes. Therefore, safe chemical regulators for TJ loosening a...

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Bibliographic Details
Main Authors: Takeshi Tenno, Kohki Kataoka, Natsuko Goda, Hidekazu Hiroaki
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
dynamic equilibrium of tight junction
drug absorption enhancer
drug repositioning
hierarchical clustering
NMR screening
non-steroidal anti-inflammatory drugs
Online Access:https://www.mdpi.com/1422-0067/22/5/2583

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https://www.mdpi.com/1422-0067/22/5/2583

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