Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

Protein quality control in the nucleolus safeguards recovery of epigenetic regulators after heat shock

Maintenance of epigenetic modifiers is of utmost importance to preserve the epigenome and consequently appropriate cellular functioning. Here, we analyzed Polycomb group protein (PcG) complex integrity in response to heat shock (HS). Upon HS, various Polycomb Repressive Complex (PRC)1 and PRC2 subun...

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Bibliographic Details
Main Authors: Maria Azkanaz, Aida Rodríguez López, Bauke de Boer, Wouter Huiting, Pierre-Olivier Angrand, Edo Vellenga, Harm H Kampinga, Steven Bergink, Joost HA Martens, Jan Jacob Schuringa, Vincent van den Boom
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
Polycomb
epigenetics
heat shock
protein quality control
leukemia
nucleolus
Online Access:https://elifesciences.org/articles/45205

Internet

https://elifesciences.org/articles/45205

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