A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish.

A GFP-Tagged Gross Deletion on Chromosome 1 Causes Malignant Peripheral Nerve Sheath Tumors and Carcinomas in Zebrafish.

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive soft-tissue sarcomas, characterized by complex karyotypes. The molecular bases of such malignancy are poorly understood and efficient targeted molecular therapies are currently lacking. Here we describe a novel zebrafish model o...

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Bibliographic Details
Main Authors: Matteo Astone, Marco Pizzi, Margherita Peron, Alice Domenichini, Vincenza Guzzardo, Sonja Töchterle, Natascia Tiso, Massimo Rugge, Dirk Meyer, Francesco Argenton, Andrea Vettori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4687860?pdf=render

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http://europepmc.org/articles/PMC4687860?pdf=render

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