HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment

HIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment

HIV-1 infection is frequently associated with low bone density, which can progress to osteoporosis leading to a high risk of fractures. Only a few mechanisms have been proposed to explain the enhanced osteolysis in the context of HIV-1 infection. As macrophages are involved in bone homeostasis and a...

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Bibliographic Details
Main Authors: Rémi Mascarau, Florent Bertrand, Arnaud Labrousse, Isabelle Gennero, Renaud Poincloux, Isabelle Maridonneau-Parini, Brigitte Raynaud-Messina, Christel Vérollet
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
HIV-1
macrophages
osteoclasts
bone defects
RANK-L
cell migration
Online Access:https://www.mdpi.com/1422-0067/21/9/3154

Internet

https://www.mdpi.com/1422-0067/21/9/3154

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