Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Melatonin inhibits the caspase-1/cytochrome c/caspase-3 cell death pathway, inhibits MT1 receptor loss and delays disease progression in a mouse model of amyotrophic lateral sclerosis

Caspase-mediated cell death contributes to the pathogenesis of motor neuron degeneration in the mutant SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS), along with other factors such as inflammation and oxidative damage. By screening a drug library, we found that melatonin, a p...

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Bibliographic Details
Main Authors: Yi Zhang, Anna Cook, Jinho Kim, Sergei V. Baranov, Jiying Jiang, Karen Smith, Kerry Cormier, Erik Bennett, Robert P. Browser, Arthur L. Day, Diane L. Carlisle, Robert J. Ferrante, Xin Wang, Robert M. Friedlander
Format: Article
Language:English
Published: Elsevier 2013-07-01
Series:Neurobiology of Disease
Subjects:
Melatonin
Caspases
Cytochrome c
Apoptosis
Melatonin receptor 1A
Amyotrophic lateral sclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611300096X

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http://www.sciencedirect.com/science/article/pii/S096999611300096X

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