DNA Break Mapping Reveals Topoisomerase II Activity Genome-Wide

DNA Break Mapping Reveals Topoisomerase II Activity Genome-Wide

Genomic DNA is under constant assault by endogenous and exogenous DNA damaging agents. DNA breakage can represent a major threat to genome integrity but can also be necessary for genome function. Here we present approaches to map DNA double-strand breaks (DSBs) and single-strand breaks (SSBs) at...

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Bibliographic Details
Main Authors: Laura Baranello, Fedor Kouzine, Damian Wojtowicz, Kairong Cui, Teresa M. Przytycka, Keji Zhao, David Levens
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:International Journal of Molecular Sciences
Subjects:
topoisomerases
DNA damage
transcription
Online Access:http://www.mdpi.com/1422-0067/15/7/13111

Internet

http://www.mdpi.com/1422-0067/15/7/13111

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