Human pluripotent stem cell differentiation to functional pancreatic cells for diabetes therapies: Innovations, challenges and future directions

Abstract Recent advances in the expansion and directed pancreatogenic differentiation of human pluripotent stem cells (hPSCs) have intensified efforts to generate functional pancreatic islet cells, especially insulin-secreting β-cells, for cell therapies against diabetes. However, the consistent gen...

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Bibliographic Details
Main Authors: Elena F. Jacobson, Emmanuel S. Tzanakakis
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Biological Engineering
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13036-017-0066-3