Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics

While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will fo...

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Bibliographic Details
Main Authors: Bai Ji, Benjamin R. E. Harris, Yahui Liu, Yibin Deng, Sergio A. Gradilone, Margot P. Cleary, Jianhua Liu, Da-Qing Yang
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
p53
Online Access:http://www.mdpi.com/1422-0067/18/1/93