Evolution of C, D and S-type cystatins in mammals: an extensive gene duplication in primates.

Cystatins are a family of inhibitors of cysteine peptidases that comprises the salivary cystatins (D and S-type cystatins) and cystatin C. These cystatins are encoded by a multigene family (CST3, CST5, CST4, CST1 and CST2) organized in tandem in the human genome. Their presence and functional import...

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Bibliographic Details
Main Authors: Patrícia de Sousa-Pereira, Joana Abrantes, Ana Pinheiro, Bruno Colaço, Rui Vitorino, Pedro J Esteves
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0109050