Increased Cystatin C in Astrocytes of Transgenic Mice Expressing the K670N-M671L Mutation of the Amyloid Precursor Protein and Deposition in Brain Amyloid Plaques

Increased Cystatin C in Astrocytes of Transgenic Mice Expressing the K670N-M671L Mutation of the Amyloid Precursor Protein and Deposition in Brain Amyloid Plaques

Cystatin C is an essential secretory cofactor for neurogenesis with potent protease inhibitor activities. Polymorphisms of cystatin C are genetically associated with Alzheimer's disease (AD), and the L68Q mutation causes hereditary cerebral hemorrhage with amyloidosis of the Icelandic type, in...

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Bibliographic Details
Main Authors: Tiana Steinhoff, Eva Moritz, M.Axel Wollmer, M.Hasan Mohajeri, Stefan Kins, Roger M. Nitsch
Format: Article
Language:English
Published: Elsevier 2001-08-01
Series:Neurobiology of Disease
Subjects:
cystatin C
β-amyloid
Alzheimer disease
transgenic models
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101904127

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http://www.sciencedirect.com/science/article/pii/S0969996101904127

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