Translational Assessment of Drug‐Induced Proximal Tubule Injury Using a Kidney Microphysiological System

Drug‐induced kidney injury, a major cause of acute kidney injury, results in progressive kidney disease and is linked to increased mortality in hospitalized patients. Primary injury sites of drug‐induced kidney injury are proximal tubules. Clinically, kidney injury molecule‐1, an established tubule‐...

Full description

Bibliographic Details
Main Authors: Christian Maass, Nathan B. Sorensen, Jonathan Himmelfarb, Edward J. Kelly, Cynthia L. Stokes, Murat Cirit
Format: Article
Language:English
Published: Wiley 2019-05-01
Series:CPT: Pharmacometrics & Systems Pharmacology
Online Access:https://doi.org/10.1002/psp4.12400