Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway

Acute Kidney Injury Induces Remote Cardiac Damage and Dysfunction Through the Galectin-3 Pathway

Summary: Acute kidney injury is associated with increased risk of heart failure and mortality. This study demonstrates that acute kidney injury induces remote cardiac dysfunction, damage, injury, and fibrosis via a galectin-3 (Gal-3) dependent pathway. Gal-3 originates from bone marrow-derived immun...

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Bibliographic Details
Main Authors: Mathilde Prud’homme, PhD, Maxime Coutrot, MD, MSc, Thibault Michel, MD, MSc, Louis Boutin, MD, MSc, Magali Genest, PhD, Françoise Poirier, PhD, Jean-Marie Launay, PharmD, PhD, Bocar Kane, Satoshi Kinugasa, MD, PhD, Niki Prakoura, PhD, Sophie Vandermeersch, Alain Cohen-Solal, MD, PhD, Claude Delcayre, PhD, Jane-Lise Samuel, MD, PhD, Ravindra Mehta, MD, Etienne Gayat, MD, PhD, Alexandre Mebazaa, MD, PhD, Christos E. Chadjichristos, PhD, Matthieu Legrand, MD, PhD
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:JACC: Basic to Translational Science
Online Access:http://www.sciencedirect.com/science/article/pii/S2452302X19301883

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http://www.sciencedirect.com/science/article/pii/S2452302X19301883

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