Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model

Mitochondrial DNA Affects the Expression of Nuclear Genes Involved in Immune and Stress Responses in a Breast Cancer Model

Tumor cells without mitochondrial (mt) DNA (ρ0 cells) are auxotrophic for uridine, and their growth is supported by pyruvate. While ATP synthesis in ρ0 cells relies on glycolysis, they fail to form tumors unless they acquire mitochondria from stromal cells. Mitochondrial acquisition restores respira...

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Bibliographic Details
Main Authors: Carole Grasso, David A. Eccles, Stepana Boukalova, Marie-Sophie Fabre, Rebecca H. Dawson, Jiri Neuzil, Patries M. Herst, Michael V. Berridge
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Physiology
Subjects:
mitochondrial DNA
gene expression
breast cancer
4T1 model
tumor macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2020.543962/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2020.543962/full

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