Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies

Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies

Ubiquitin, a protein modifier that regulates diverse essential cellular processes, is also a component of the protein inclusions characteristic of many neurodegenerative disorders. In Alzheimer’s disease, the microtubule associated tau protein accumulates within damaged neurons in the form of cross-...

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Bibliographic Details
Main Authors: Francesca Munari, Carlo Giorgio Barracchia, Francesca Parolini, Roberto Tira, Luigi Bubacco, Michael Assfalg, Mariapina D’Onofrio
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
tau protein
ubiquitination
semisynthesis
disulfide-coupling
polyubiquitin
fibrils
Online Access:https://www.mdpi.com/1422-0067/21/12/4400

Internet

https://www.mdpi.com/1422-0067/21/12/4400

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