Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial

Permissive versus restrictive temperature thresholds in critically ill children with fever and infection: a multicentre randomized clinical pilot trial

Abstract Background Fever improves pathogen control at a significant metabolic cost. No randomized clinical trials (RCT) have compared fever treatment thresholds in critically ill children. We performed a pilot RCT to determine whether a definitive trial of a permissive approach to fever in comparis...

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Bibliographic Details
Main Authors: Mark J. Peters, Kerry Woolfall, Imran Khan, Elisabeth Deja, Paul R. Mouncey, Jerome Wulff, Alexina Mason, Rachel S. Agbeko, Elizabeth S. Draper, Blaise Fenn, Doug W. Gould, Abby Koelewyn, Nigel Klein, Christine Mackerness, Sian Martin, Lauran O’Neill, Samiran Ray, Padmanabhan Ramnarayan, Shane Tibby, Kentigern Thorburn, Lyvonne Tume, Jason Watkins, Paul Wellman, David A. Harrison, Kathryn M. Rowan, the FEVER Investigators on behalf of the Paediatric Intensive Care Society Study Group (PICS-SG)
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Critical Care
Subjects:
Sepsis
Infection
Paediatric intensive care
Fever
Paracetamol
Antipyretics
Online Access:http://link.springer.com/article/10.1186/s13054-019-2354-4

Internet

http://link.springer.com/article/10.1186/s13054-019-2354-4

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