Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity.

Crystal structures of H-2Db in complex with the LCMV-derived peptides GP92 and GP392 explain pleiotropic effects of glycosylation on antigen presentation and immunogenicity.

Post-translational modifications significantly broaden the epitope repertoire for major histocompatibility class I complexes (MHC-I) and may allow viruses to escape immune recognition. Lymphocytic choriomeningitis virus (LCMV) infection of H-2b mice generates CD8+ CTL responses directed towards seve...

Full description

Bibliographic Details
Main Authors: Ida Hafstrand, Daniel Badia-Martinez, Benjamin John Josey, Melissa Norström, Jérémie Buratto, Sara Pellegrino, Adil Doganay Duru, Tatyana Sandalova, Adnane Achour
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5734757?pdf=render

Internet

http://europepmc.org/articles/PMC5734757?pdf=render

Similar Items