Ashwagandha (Withania somnifera) supercritical CO2 extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells

Ashwagandha (Withania somnifera) supercritical CO2 extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells

Bisphenol A (BPA) safety aspects on human health are debated extensively for long time. In the present study, we have studied the toxicity induced by BPA at no observed adverse effect level (NOAEL) using HepG2 cells. We report that BPA at 100 nM induced cytotoxicity to HepG2 cells as determined by M...

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Bibliographic Details
Main Authors: Satyakumar Vidyashankar, O.S. Thiyagarajan, R.Sandeep Varma, L.M. Sharath Kumar, Uddagiri Venkanna Babu, Pralhad Sadashiv Patki
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Toxicology Reports
Subjects:
Bisphenol A
HepG2 cells
Ashwagandha
Mitochondrial toxicity
Glutathione
Antioxidant enzymes
Online Access:http://www.sciencedirect.com/science/article/pii/S2214750014000420

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http://www.sciencedirect.com/science/article/pii/S2214750014000420

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