Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation.

Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation.

Mutations at position K171 in the kinase activation loop of Inhibitor of κB kinase beta (IKKβ) occur in multiple myeloma, spleen marginal zone lymphoma and mantle cell lymphoma. Previously, we demonstrated that these result in constitutive kinase activation and stimulate Signal Transducer and Activa...

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Bibliographic Details
Main Authors: April N Meyer, Leandro H Gallo, Juyeon Ko, Guillermo Cardenas, Katelyn N Nelson, Asma Siari, Alexandre R Campos, Thomas C Whisenant, Daniel J Donoghue
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6193727?pdf=render

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http://europepmc.org/articles/PMC6193727?pdf=render

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