SHh activity and localization is regulated by perlecan

Proliferation and cell fate determination in the developing embryo are extrinsically regulated by multiple interactions among diverse secreted factors, such as Sonic Hedgehog (SHh), which act in a concentration-dependent manner. The fact that SHh is secreted as a lipid-modified protein suggests the...

Full description

Bibliographic Details
Main Authors: Verónica Palma, Héctor Carrasco, Gisela Reinchisi, Gonzalo Olivares, Fernando Faunes, Juan Larraín
Format: Article
Language:English
Published: BMC 2011-01-01
Series:Biological Research
Subjects:
SHh
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100008