SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism

Maintenance of skeletal muscle is beneficial in obesity and Type 2 diabetes. Mechanical stimulation can regulate skeletal muscle differentiation, growth and metabolism; however, the molecular mechanosensor remains unknown. Here, we show that SWELL1 (Lrrc8a) functionally encodes a swell-activated ani...

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Bibliographic Details
Main Authors: Ashutosh Kumar, Litao Xie, Chau My Ta, Antentor O Hinton, Susheel K Gunasekar, Rachel A Minerath, Karen Shen, Joshua M Maurer, Chad E Grueter, E Dale Abel, Gretchen Meyer, Rajan Sah
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
VRAC
ion channel
knock-out mouse
growth
Online Access:https://elifesciences.org/articles/58941

Internet

https://elifesciences.org/articles/58941

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