Polycomb condensates can promote epigenetic marks but are not required for sustained chromatin compaction
Phase separation has been suggested as a mechanism for heterochromatin formation through condensation of heterochromatin-associated factors. Here the authors show Polycomb complex PRC1 forms condensates on chromatin. Using optogenetic tools they nucleate local Polycomb condensates to show that this...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-10-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26147-5 |