Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury

Fibroblasts in Nodular Sclerosing Classical Hodgkin Lymphoma Are Defined by a Specific Phenotype and Protect Tumor Cells from Brentuximab-Vedotin Induced Injury

Classical Hodgkin lymphoma (cHL) is one of the most common malignant lymphomas in Western Europe. The nodular sclerosing subtype of cHL (NS cHL) is characterized by a proliferation of fibroblasts in the tumor microenvironment, leading to fibrotic bands surrounding the lymphoma infiltrate. Several st...

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Bibliographic Details
Main Authors: Katrin Bankov, Claudia Döring, Adam Ustaszewski, Maciej Giefing, Marco Herling, Chiara Cencioni, Francesco Spallotta, Carlo Gaetano, Ralf Küppers, Martin-Leo Hansmann, Sylvia Hartmann
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
classical hodgkin lymphoma
nodular sclerosis
fibroblasts
gene expression analysis
methylation profiling
luteolin
Online Access:https://www.mdpi.com/2072-6694/11/11/1687

Internet

https://www.mdpi.com/2072-6694/11/11/1687

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