An Experimental Model of Neuromyelitis Optica Spectrum Disorder–Optic Neuritis: Insights Into Disease Mechanisms

An Experimental Model of Neuromyelitis Optica Spectrum Disorder–Optic Neuritis: Insights Into Disease Mechanisms

Background: Optic neuritis (ON) is a common inflammatory optic neuropathy, which often occurs in neuromyelitis optica spectrum disease (NMOSD). An experimental model of NMOSD-ON may provide insight into disease mechanisms.Objective: To examine the pathogenicity of autoantibodies targeting the astroc...

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Bibliographic Details
Main Authors: Sofie Forsberg Soerensen, Martin Wirenfeldt, Agnieszka Wlodarczyk, Marlene Thorsen Moerch, Reza Khorooshi, Dina S. Arengoth, Soeren Thue Lillevang, Trevor Owens, Nasrin Asgari
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Neurology
Subjects:
optic neuritis
aquaporin-4 immunoglobulin G
antibody-mediated
type I interferon (IFN)
disease model animal
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2021.703249/full

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https://www.frontiersin.org/articles/10.3389/fneur.2021.703249/full

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