Pharmacological Modulation of Rate-Dependent Depression of the Spinal H-Reflex Predicts Therapeutic Efficacy against Painful Diabetic Neuropathy

Pharmacological Modulation of Rate-Dependent Depression of the Spinal H-Reflex Predicts Therapeutic Efficacy against Painful Diabetic Neuropathy

Impaired rate-dependent depression (RDD) of the spinal H-reflex occurs in diabetic rodents and a sub-set of patients with painful diabetic neuropathy. RDD is unaffected in animal models of painful neuropathy associated with peripheral pain mechanisms and diabetic patients with painless neuropathy, s...

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Bibliographic Details
Main Authors: Corinne A. Lee-Kubli, XiaJun Zhou, Corinne G. Jolivalt, Nigel A. Calcutt
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Diagnostics
Subjects:
diabetic neuropathy
painful neuropathy
spinal disinhibition
GABAergic
carbonic anhydrase
rate dependent depression
Online Access:https://www.mdpi.com/2075-4418/11/2/283

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https://www.mdpi.com/2075-4418/11/2/283

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