ATRX is a regulator of therapy induced senescence in human cells

ATRX is a regulator of therapy induced senescence in human cells

Therapy induced senescence (TIS) is a growth suppressive program activated by cytostatic agents in some cancer cells. Here the authors show that the chromatin remodeling enzyme ATRX is a regulator of TIS and drives cells into this state via multiple mechanisms.

Bibliographic Details
Main Authors: Marta Kovatcheva, Will Liao, Mary E. Klein, Nicolas Robine, Heather Geiger, Aimee M. Crago, Mark A. Dickson, William D. Tap, Samuel Singer, Andrew Koff
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00540-5

Internet

https://doi.org/10.1038/s41467-017-00540-5

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