Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes

Crucial Involvement of IL-6 in Thrombus Resolution in Mice via Macrophage Recruitment and the Induction of Proteolytic Enzymes

After the ligation of the inferior vena cava (IVC) of wild-type (WT) mice, venous thrombi formed and grew progressively until 5 days and resolved thereafter. Concomitantly, intrathrombotic gene expression of Il6 was enhanced later than 5 days after IVC ligation. IL-6 protein expression was detected...

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Bibliographic Details
Main Authors: Mizuho Nosaka, Yuko Ishida, Akihiko Kimura, Yumi Kuninaka, Akira Taruya, Mitsunori Ozaki, Atushi Tanaka, Naofumi Mukaida, Toshikazu Kondo
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
IL-6
thrombosis
macrophages
matrix metalloproteinases
proteolytic enzymes
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03150/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03150/full

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