The Putative De-N-acetylase DnpA Contributes to Intracellular and Biofilm-Associated Persistence of Pseudomonas aeruginosa Exposed to Fluoroquinolones

The Putative De-N-acetylase DnpA Contributes to Intracellular and Biofilm-Associated Persistence of Pseudomonas aeruginosa Exposed to Fluoroquinolones

Persisters are the fraction of antibiotic-exposed bacteria transiently refractory to killing and are recognized as a cause of antibiotic treatment failure. The putative de-N-acetylase DnpA increases persister levels in Pseudomonas aeruginosa upon exposure to fluoroquinolones in broth. In this study...

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Bibliographic Details
Main Authors: Shaunak Khandekar, Veerle Liebens, Maarten Fauvart, Paul M. Tulkens, Jan Michiels, Françoise Van Bambeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
de-N-acetylase
gyrase
persister
fluoroquinolones
intracellular infection
biofilm
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01455/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01455/full

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