Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3β Signaling Pathway in Human Hepatocellular Carcinoma

Erinacine Facilitates the Opening of the Mitochondrial Permeability Transition Pore Through the Inhibition of the PI3K/ Akt/GSK-3β Signaling Pathway in Human Hepatocellular Carcinoma

Background/Aims: Erinacine, which is extracted from the medicinal mushroom Hericium erinaceus, is known to play anticancer roles in human cancers. The following study aims to investigate the role of erinacine in the opening of the mitochondrial permeability transition pore (MPTP) in hepatocellular c...

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Bibliographic Details
Main Authors: Li-Jie Zhou, Yan-Bo Mo, Xuan Bu, Jian-Jun Wang, Jing Bai, Jun-Wei Zhang, Ai-Bin Cheng, Ji-Hong Ma, Yi-Wei Wang, Yu-Xi  Xie
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
Erinacine
Hepatocellular carcinoma
Mitochondrial permeability transition pore
PI3K/Akt/GSK-3β signaling pathway
LY294002
Online Access:https://www.karger.com/Article/FullText/494472

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https://www.karger.com/Article/FullText/494472

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