Induction of hematopoietic microchimerism by gene-modified BMT elicits antigen-specific B and T cell unresponsiveness toward gene therapy products

Induction of hematopoietic microchimerism by gene-modified BMT elicits antigen-specific B and T cell unresponsiveness toward gene therapy products

Background: Gene therapy is a promising treatment option for hemophilia and other protein deficiencies. However, immune responses against the transgene product represent an obstacle to safe and effective gene therapy, urging for the implementation of tolerization strategies. Induction of a hematopoi...

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Bibliographic Details
Main Authors: Jérémie Martinet, Gwladys Bourdenet, Amine Meliani, Laetitia Jean, Sahil Adriouch, José Cohen, Federico Mingozzi, Olivier Boyer
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Immunology
Subjects:
Gene Therapy
Hemophilia B
tolerance
animal model
microchimerism
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00360/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00360/full

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