Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysis.

BACKGROUND:Leptospirosis is an important zoonotic disease worldwide. Humans usually present a mild non-specific febrile illness, but a proportion of them develop more severe outcomes, such as multi-organ failure, lung hemorrhage and death. Such complications are thought to depend on several factors,...

Full description

Bibliographic Details
Main Authors: Carolina Lessa-Aquino, Janet C Lindow, Arlo Randall, Elsio Wunder, Jozelyn Pablo, Rie Nakajima, Algis Jasinskas, Jaqueline S Cruz, Alcineia O Damião, Nívison Nery, Guilherme S Ribeiro, Federico Costa, José E Hagan, Mitermayer Galvão Reis, Albert I Ko, Marco Alberto Medeiros, Philip L Felgner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC5302828?pdf=render