Single-Center Experience With Epigenetic Treatment for Juvenile Myelomonocytic Leukemia

Single-Center Experience With Epigenetic Treatment for Juvenile Myelomonocytic Leukemia

Background: Juvenile myelomonocytic leukemia (JMML) is a rare myelodysplastic/myeloproliferative neoplasm diagnosed in young children, characterized by somatic or germline mutations that lead to hyperactive RAS signaling. The only curative option is hematopoietic stem cell transplantation (HSCT). Re...

Full description

Bibliographic Details
Main Authors: Andra Marcu, Andrei Colita, Letitia Elena Radu, Cristina Georgiana Jercan, Ana Maria Bica, Minodora Asan, Daniel Coriu, Alina Daniela Tanase, Carmen C. Diaconu, Cristina Mambet, Anca Botezatu, Sergiu Pasca, Patric Teodorescu, Gabriela Anton, Petruta Gurban, Anca Colita
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
juvenile myelomonocytic leukemia
mutation
epigenetics
methylation
azacytidine
hematopoietic stem cell transplantation
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00484/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00484/full

Similar Items