Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1

Novel Spiroannulated 3-Benzofuranones. Synthesis and Inhibition of the Human Peptidyl Prolyl cis/trans Isomerase Pin1

The novel 3H-spiro[1-benzofuran-2-cyclopentan]-3-one skeleton has been madeaccessible by different routes. One- and two-step protocols lead to tricyclic and tetracyclicbenzofuranones 2 and 3, respectively. A four-step synthesis to spirocompound 4 isdescribed. The novel spirocyclic benzofuranones dis...

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Bibliographic Details
Main Authors: Gunter Fischer, Birte Hernandez Alvarez, Boris Féaux de Lacroix, Anahita Hessamian-Alinejad, Manfred Braun
Format: Article
Language:English
Published: MDPI AG 2008-04-01
Series:Molecules
Subjects:
Ketones
lithiation
cyclization
metathesis
spiroannulation
Online Access:http://www.mdpi.com/1420-3049/13/4/995/

Internet

http://www.mdpi.com/1420-3049/13/4/995/

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