RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes.

RNF8 and SCML2 cooperate to regulate ubiquitination and H3K27 acetylation for escape gene activation on the sex chromosomes.

The sex chromosomes are enriched with germline genes that are activated during the late stages of spermatogenesis. Due to meiotic sex chromosome inactivation (MSCI), these sex chromosome-linked genes must escape silencing for activation in spermatids, thereby ensuring their functions for male reprod...

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Bibliographic Details
Main Authors: Shannel R Adams, So Maezawa, Kris G Alavattam, Hironori Abe, Akihiko Sakashita, Megan Shroder, Tyler J Broering, Julie Sroga Rios, Michael A Thomas, Xinhua Lin, Carolyn M Price, Artem Barski, Paul R Andreassen, Satoshi H Namekawa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-02-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1007233

Internet

https://doi.org/10.1371/journal.pgen.1007233

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