Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Therapeutic Inhibition of Cathepsin S Reduces Inflammation and Mucus Plugging in Adult βENaC-Tg Mice

Background. Elevated levels of the cysteine protease cathepsin S (CatS) are associated with chronic mucoobstructive lung diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). We have previously demonstrated that prophylactic treatment with a CatS inhibitor from birt...

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Bibliographic Details
Main Authors: Ryan Brown, Donna M. Small, Declan F. Doherty, Leslie Holsinger, Robert Booth, Richard Williams, Rebecca J. Ingram, J. Stuart Elborn, Marcus A. Mall, Clifford C. Taggart, Sinéad Weldon
Format: Article
Language:English
Published: Hindawi Limited 2021-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2021/6682657

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http://dx.doi.org/10.1155/2021/6682657

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